Viral replication within cells is inhibited directly by :

1. Viral replication within cells is inhibited directly by :

A) IFN-γ
B) TNF-α
C) IL-1
D) IL-4

... Answer is A). IFN-γ

IFN-γ is mainly produced by natural killer (NK) cells, NK T-cells and after antigen stimulation by CD4 T-helper cells and CD2 cytotoxic T cells. Although IFN-γ can under certain circumstances directly inhibit viral replication, its main antiviral capability is derived from its immunostimulatory and immunomodulatory effects. It plays an important role in shaping the adaptive immune response by promoting antigen driven T-cell proliferation and homeostatic control of antigen-specific CTL numbers.